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Re: Glue carcinogenicity
"[...]Vinyl acetate monomer is an important compound used in the
plastics industry.
It is also used in the production of resin in chewing gum.
The limited available epidemiological data on vinyl acetate monomer
do not allow for an evaluation of its potential carcinogenic risks
in human beings.
Carcinogenicity studies on rats and mice,
conducted prior to the most recent
International Agency for Research on Cancer evaluation [4],
have been in one way or another inadequate
to evaluate the carcinogenic potential of vinyl acetate monomer.
In the 1980s, a series of experiments were simultaneously
conducted at the CMCRC/ERF using Sprague-Dawley rats,
Wistar rats and Swiss mice.
A similar protocol was applied for all three experiments.
Vinyl acetate monomer was administered by ingestion
in drinking water supplied ad libitum at the concentrations of
5000, 1000 or 0 p.p.m. to
17-week-old males and females (breeders)
and 12-day-old embryos (offspring).
The treatment lasted 104 weeks in rats and 78 weeks in mice.
All animals were monitored until natural death (130-150 weeks).
The plan of each experiment and the significant carcinogenic
results are reported in tables 2-4.
In the tested conditions, vinyl acetate monomer was demonstrated
to be a multipotent carcinogenic agent, inducing malignant tumours
of the oral cavity, tongue, oesophagus and forestomach
in both strains of rats and mice.
A slight increase of the incidence
of adenomas/carcinomas of the lung
and of malignant tumours of the uterus in mice
was also observed [5-7].
Furthermore, the carcinogenic effects
were strongly increased when exposure
began during foetal life. [...]"
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