There is no way any tapes or glues will `damage` hair follicles in the same way that a plaster applied to a wound would cause any damage to your body --follicles are below the skin,therefore, don`t come into contact with any products directly -- the only reaction you may possibly experience, depending on your own body type, may be an itch or maybe redness, which is more to do with allergies --if you experience anything like that, just try a different product until you find one which suits you -- personally, I take my system off nightly, and leave it off overnight, followed with a shower every morning before I re -attach. I know that may not be practical for everyone, depending on your circumstances, but in the past, when I was attending these ``Salons/hair clubs``, an all -poly system was attached to my head by painting the entire scalp with glue, and then sitting the system onto it --this was left in place for anything up to 4 weeks !! Can you imagine what that was like when it was removed for cleaning? It`s only a wonder I never got some kind of infection in the scalp ----your scalp, like all of the body, is constantly losing microscopic pieces of dead skin /tissue, along with the scalp exuding oils [even when you have lost your hair, the scalp still produces oils] I eventually did begin to see large red areas of skin and had to apply anti -septic creams to soothe it ---in my view, cleanliness is the key, so don`t leave a system on too long without cleaning the scalp --- at least with lace systems, the scalp can `breath` except around the perimeter where the glue/tape is, so that is the main area to ``keep an eye`` on ---- if you experience any type of allergic reaction, simply try using a different adhesive /tape.